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Sodium borohydride → tert-butyl N-[3-(hydroxymethyl)cyclohexyl]carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Methyl 3-(tert-butoxycarbonylamino)cyclohexanecarboxylate | HCID 59453914 | — |
| 溶媒 | methanol THF dichloromethane | HCID 22912779 | — |
| 生成物 | tert-butyl N-[3-(hydroxymethyl)cyclohexyl]carbamate | HCID 22106830 | — |
反応手順
To a solution of methyl 3-(tert-butoxycarbonylamino)cyclohexanecarboxylate (9 mmol) in THF/MeOH/CH2Cl2 (36 ml, 10:1:1) was added NaBH4 (22.5 mmol) and stirred at rt overnight. The reaction was quenched with water and extracted with CH2Cl2 (3×10 mL). The extracts were combined and dried using anhydrous sodium sulfate. The product was purified using Biotage.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09351965B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-a5507b277d9543b8a7e79c784e16ef3d |
| 出典メモ | uspto-grants-2016_05 |