反应详情

温度

95 °C

In a clean round bottom flask, 10.0 gms of 1[(4-Methylquinazolin-2yl) methyl]-3-methyl-7-(2-butin-1yl)-8-(3(R)-4-methyl phthalimidopiperidine-yl)-xanthine and 50 ml ethanolamine were charged. The reaction mass was heated to 90-100° C. for 1 hr and cooled to room temperature. 100 ml water was added and the solid was filtered. 150 ml of toluene was added and completely distilled out under vacuum at 45-50° C. to get pale yellow solid. Dry wt: 6.0 gm.

1. temperaturecooled to room temperature
2. filtrationthe solid was filtered
3. addition150 ml of toluene was added
4. distillationcompletely distilled out under vacuum at 45-50° C.
5. customto get pale yellow solid
6. customDry