反应详情

4-methoxy-phenethyl alcohol (15.2 g, 10 mmol) were dissolved in 200 ml of dichloromethane and at 0° C., 7.35 ml of thionyl chloride were added. The reaction mixture was allowed to warm to room temperature over 1/2 hour. After stirring for 20 hours, the mixture was added to brine and extracted with dichloromethane. The dichloromethane was evaporated to obtain an oil which was chromatographed on silica gel using a mixture of 30% ethyl acetate/hexane as the eluent to obtain 8.8 g (51%) of the title product.

1. extractionextracted with dichloromethane
2. customThe dichloromethane was evaporated
3. customto obtain an oil which
4. customwas chromatographed on silica gel using
5. additiona mixture of 30% ethyl acetate/hexane as the eluent