反应详情

温度

80 °C

Manganese dioxide (14.7 g) was added at room temperature to a toluene (80 mL) solution of (4,5-dicyclopropyl-2-isopropoxyphenyl)methanol (5.22 g), and the mixture was stirred at 80° C. for 1 hour in a nitrogen atmosphere. The reaction mixture was filtered through celite, and then, the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (4.88 g).

1. filtrationThe reaction mixture was filtered through celite
2. concentrationthe filtrate was concentrated
3. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)