(2-Cyclopropyl-5-ethoxy-2',4'-difluorobiphenyl-4-yl)methanol → 2-Cyclopropyl-5-ethoxy-2',4'-difluorobiphenyl-4-carbaldehyde

Participants

Reaction Conditions

Reaction Steps

Manganese dioxide (45.9 g) was added to a toluene (80 mL) solution of (2-cyclopropyl-5-ethoxy-2′,4′-difluorobiphenyl-4-yl)methanol (16.1 g), and the mixture was stirred at 60° C. for 1 hour in a nitrogen atmosphere. The reaction mixture was filtered, and then, the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (12.8 g).

Provenance & Evidence