HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromotrimethylsilane → 6-Methoxy-2-naphthylthiomethanediphosphonic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | Tetraethyl 6-methoxy-2-naphthylthiomethanediphosphonate | HCID 86750675 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Methoxy-2-naphthylthiomethanediphosphonic Acid | HCID 86750674 | 80.6% |
Reaction Steps
Following the same method described as in Example 2, 7.15 g (15 mmol) of tetraethyl 6-methoxy-2-naphthylthiomethanediphosphonate obtained in Example 3 in dry methylene chloride was treated with trimethylsilyl bromide, and then hydrolyzed to obtain 4.21 g of the title compound as white crystals. The yield was 77%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05618804 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-25ec6e787a3f4a23aa117cf2e6b6a982 |
| Source note | uspto-grants-1997_04 |