HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromotrimethylsilane → 2-[3-Methylthio-4-hydroxy-1-naphthyl]ethane-1,1-diphosphonic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | Tetraethyl 2-[3-methylthio-4-hydroxy-1-naphthyl]ethane-1,1-diphosphonate | HCID 19961546 | — |
| Product | 2-[3-Methylthio-4-hydroxy-1-naphthyl]ethane-1,1-diphosphonic Acid | HCID 19961547 | 71% |
Reaction Steps
Following the same method as described in Example 2, 7.36 g (15 mmol) of tetraethyl 2-[3-methylthio-4-hydroxy-1-naphthyl]ethane-1,1-diphosphonate was treated with trimethylsilyl bromide, and then hydrolysis was effected to obtain 4.03 g of the title compound as pale yellow crystals. The yield was 71%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05618804 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-26308c9556f246f8a76e632366e3a982 |
| Source note | uspto-grants-1997_04 |