Nitrogen → HCID 86730387, compound

Participants

Reaction Steps

A solution of Compound 11 (300 mg, 0.85 mmol) in dry THF was sparged with N2, then NaH (68 mg of 60% dispersion, 1.7 mmol) was added in a single portion. While still sparging with N2, 4-nitrophenyl chloroformate (341 mg, 1.7 mmol) was added and the reaction stirred at room temperature for 1 hour. Solvent was evaporated by rotary evaporator and the product precipitated from ethyl acetate/diethyl ether and filtered. The crude solid was washed with methanol (20 mL) to yield Compound 12 as crude yellow solid, which was taken directly to the next reaction.

Provenance & Evidence