tert-Butyl methyl ether → (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-bromo-2-(methylsulfonyl)pyrimidin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one

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Reaction Steps

To a suspension of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one (INTERMEDIATE 8, 10 g, 18.86 mmol) in acetonitrile (25 mL) and water (25 mL) was added potassium peroxymonosulfate (27.8 g, 45.3 mmol). After it was stirred at room for 14 hours, LCMS showed complete conversion of the starting material. It was distributed between water (200 mL) and t-butyl methyl ether (300 mL). The organic layer was washed with water (200 mL) and brine, dried over sodium sulfate, filtered and the filtrate concentrated to get the title compound (10.2 g, 96% yield) as a brightly white solid. LCMS (M+H)+: 564.05. 1H NMR (CDCl3, 500 MHz): δ 8.99 (s, 1H), 7.93 (s, 1H), 7.84 (s, 2H), 6.02 (d, 8.5 Hz, 1H), 5.14 (d, 18.5 Hz, 1H), 4.56 (m, 1H), 4.42 (d, 18.0 Hz, 1H), 3.37 (S, 3H), 0.86 (d, 6.5 Hz, 3H).

Provenance & Evidence