Potassium Phosphate, Tribasic → Methyl 4-{5-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-6-methoxypyridin-3-yl}-3,5-dimethylbenzoate

Participants

Reaction Steps

(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-3-{[2-(methylthio)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-4-yl]methyl}-1,3-oxazolidin-2-one (INTERMEDIATE 21, 1.12 g, 1.940 mmol), methyl 4-(5-bromo-6-methoxypyridin-3-yl)-3,5-dimethylbenzoate (INTERMEDIATE 33, 0.815 g, 2.328 mmol) and Pd(Ph3P)4 (0.224 g, 0.194 mmol) were evacuated and charged with nitrogen. Added 1,4-dioxane (9.70 mL) and 2N tribasic potassium phosphate (2.91 mL, 5.82 mmol), then stirred at 170° C. for 10 minutes in a microwave reactor. LCMS showed significant product formation. The crude was purified directly by silica gel chromatography, eluting with a gradient of 5-40% ethyl acetate/hexanes over 10 column volumes to give the title compound. 1H NMR (CDCl3, 500 MHz): δ 8.36 (s, 1H), 8.07 (d, 1H), 7.89 (s, 1H), 7.81 (s, 2H), 7.74 (s, 2H), 7.33 (d, 1H), 5.73 (d, 1H), 4.81 (d, 1H), 4.44 (br, 1H), 4.08 (m, 1H), δ4.01 (s, 3H), 3.93 (s, 3H), 2.62 (s, 3H), 2.16 (s, 3H), 2.14 (s, 3H), 0.75 (d, 3H).

Provenance & Evidence