tert-Butyl methyl ether → 4-{5-[4-({(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfonyl)pyrimidin-5-yl]-4-methyl-1,3-thiazol-2-yl}-3-methylbenzoic acid

Participants

Reaction Conditions

Reaction Steps

4-{5-[4-({(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylthio)pyrimidin-5-yl]-4-methyl-1,3-thiazol-2-yl}-3-methylbenzoic acid (INTERMEDIATE 53, 2.2 g, 3.22 mmol), was dissolved in 10 mL of THF and 10 mL of water. Potassium peroxymonosulfate (5.11 g, 8.31 mmol) was added, and it was stirred at 60° C. for 2 hours. Then, it was worked up with water (100 mL) and t-butyl methyl ether (200 mL). The organic layer was concentrated and purified on a silica gel column, eluting with 60% ethyl acetate in hexanes to give the title compound as a slightly yellow solid. LCMS (M+1): 715.0 1H NMR (CDCl3, 500 MHz): δ 8.93 (s, 1H), 8.93 (s, 1H), 8.10 (s, 1H), 8.03 (d, 8.5 Hz, 1H), 7.93 (m, 2H), 7.82 (s, 2H), 6.00 (d, 8.5 Hz, 1H), 5.08 (d, 16.5 Hz, 1H), 4.67 (m, 1H), 4.31 (d, 16.6 Hz, 1H), 3.46 (s, 3H), 2.75 (s, 3H), 2.50 (s, 3H), 0.86 (d, 6.5 Hz, 3H).

Provenance & Evidence