Morpholine → HCID 72191835, compound

Participants

Reaction Conditions

Reaction Steps

Morpholine (0.217 mL, 2.488 mmol) was added to a THF (1 mL) solution of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-(5-chloro-2-methoxypyridin-3-yl)-2-(methylsulfonyl)pyrimidin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one (Step A, 311 mg, 0.498 mmol). This was then stirred for 30 minutes at 120° C. in a microwave reactor. LCMS showed >90% conversion to product. The reaction was concentrated on rotary evaporator. The crude isolate was purified by silica gel chromatography, eluting with a 0-50% isopropyl acetate/hexanes linear gradient followed by isocratic elution with 50% isopropyl acetate/hexanes for 10 minutes to give the titled compound as a white foam. LCMS (M+H)+: 632.3. 1H NMR (CDCl3, 500 MHz): δ 8.19 (d, J=2.5 Hz, 1H), 8.16 (s, 1H), 7.91 (s, 1H), 7.75 (s, 2H), 7.48 (d, J=2.5 Hz, 1H), 5.66 (d, J=8.5 Hz, 1H), 4.72 (d, J=17.1 Hz, 1H), 4.31 (m, 1H), 3.96 (s, 3H), 3.89 (m, 4H), 3.83 (m, 4H), 0.73 (d, J=6.5 Hz, 3H). SPA IC50: 671 nM.

Provenance & Evidence