Acetonitrile → HCID 118021407, compound

Participants

Reaction Conditions

Reaction Steps

Potassium peroxymonosulfate (528 mg, 0.859 mmol) was added (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-{2-methoxy-5-[(2RS)-1,1,1-trifluoro-2-hydroxypropan-2-yl]pyridin-3-yl}-2-(methylthio)pyrimidin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one (Step A, 240 mg, 0.358 mmol) in acetonitrile (2 mL) and water (1 mL) and stirred for 1 hour at 60° C. (bath was turned off immediately and allowed to cool to 25° C. over 1 hour); LCMS showed complete conversion to product. The reaction was diluted with 20 mL methyl t-butyl ether and poured into 20 mL water; the organic layer was washed twice with water (20 mL) and finally with 50 mL brine, dried over sodium sulfate and concentrated to afford white solid.

Provenance & Evidence