Morpholine → HCID 72189070, compound

Participants

Reaction Steps

Morpholine (206 μl, 2.358 mmol), methyl 4-{5-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfonyl)pyrimidin-5-yl]-6-methoxypyridin-3-yl}-3,5-dimethylbenzoate (INTERMEDIATE 44, 355 mg, 0.472 mmol), and THF (2.4 mL) were stirred at 100° C. for 10 minutes in the microwave reactor, at which time LCMS showed complete conversion to target. The reaction was partitioned between water and ethyl acetate. The organic was then washed with brine, dried over sodium sulfate, filtered and evaporated. The crude isolate was purified by silica gel chromatography, eluting with 25-100% ethyl acetate/hexanes to give the titled compound. 1H NMR (CDCl3, 500 MHz): δ 8.16 (s, 1H), 8.01 (d, 1H), 7.89 (s, 1H), 7.80 (d, 2H), 7.73 (s, 2H), 7.27 (d, 1H), 5.66 (d, 1H), 4.72 (d, 1H), 4.32 (m, 1H), 4.00 (m, s, 4H), 3.93 (s, 3H), 3.84 (m, 4H), 3.80 (m, 4H), 2.15 (s, 3H), 2.13 (s, 3H), 0.72 (d, 3H).

Provenance & Evidence