Trifluoroacetic acid → 4-{5-[4-({(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-fluoroazetidin-1-yl)pyrimidin-5-yl]-6-methylpyridin-3-yl}-3-methylbenzoic acid

Participants

Reaction Steps

To a 25 mL round bottom flask was added tert-butyl 4-{5-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-fluoroazetidin-1-yl)pyrimidin-5-yl]-6-methylpyridin-3-yl}-3-methylbenzoate (Step A, 40 mg, 0.053 mmol) and TFA (4 mL). The mixture was stirred at room temperature for 10 minutes. Volatiles were removed. The residue was purified on silica gel chromatography (0 to 100% acetone/hexane), affording the title compound as white solid. LCMS (M+H)+: 704.1. RTA IC50: 26 nM.

Provenance & Evidence