Cyclobutylamine → HCID 72191222, compound

Participants

Reaction Conditions

Reaction Steps

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-(3,5-dimethylisoxazol-4-yl)-2-(methylsulfonyl)pyrimidin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one was dissolved in an excess amount of cyclobutylamine in THF, then heated to 150° C. for 2 hours in a microwave reactor. The reaction mixture was evaporated, then reconstituted in methanol and purified by preparative reverse phase HPLC to give the title compound. LCMS (M+H)+: 556.1. 1H NMR (CDCl3, 500 MHz): δ 8.15 (s, 1H), 7.91 (s, 1H), 7.74 (s, 2H), 5.77 (d, 1H), 4.50-4.30 (m, 6H), 3.92 (t, 1H), 2.53 (m, 2H), 2.32 (d, 3H), 2.16 (d, 3H), 0.77 (d, 3H). RTA IC50: 271 nM.

Provenance & Evidence