N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide → HCID 178487693, compound

HRID 531327Notes

Reaction equation

HRID 531327 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([C:9]([NH:11][C:12]2[C:17]([Cl:18])=[C:16]([O:19][CH3:20])[CH:15]=[CH:14][C:13]=2[C:21](=[O:23])[CH3:22])=O)[S:7][CH:8]=1)([CH3:3])[CH3:2].OC1C2C(=C(C)C(OC)=CC=2)N=C(C2SC=C(C(C)C)N=2)C=1>>[Cl:18][C:17]1[C:16]([O:19][CH3:20])=[CH:15][CH:14]=[C:13]2[C:12]=1[N:11]=[C:9]([C:6]1[S:7][CH:8]=[C:4]([CH:1]([CH3:3])[CH3:2])[N:5]=1)[CH:22]=[C:21]2[OH:23]

Participants

3

Reactant 2

HCID 56605150N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamideHCID 1784876922-(4-Isopropylthiazol-2-YL)-7-methoxy-8-methylquinolin-4-OL

Product 1

HCID 178487693HCID 178487693, compound

Procedure

The title product 52 was prepared (58%) from 2′-[[(4-isopropylthiazole-2-yl)(oxo)-methyl]amino]-3′-chloro-4′-methoxyacetophenone (51) following the procedure reported for 4-hydroxy-2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinoline (36): m/z=335 (M+H)+.

Sources & evidence

ORD record
ord-c98db24b6cd641169a6471851f83ec81
Source dataset
uspto-grants-2016_05
Patent number
US09353103B2

Reaction notes

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