3-bromo-5-phenyl-8-ethyl-2,3,4,5-tetrahydro-1H-(1)benzazepin-2-one → N-(1-Methylcyclohexyl)2-[3-bromo-2-oxo-5-phenyl-8-ethyl-2,3,4,5,-tetrahydro-1H-(1)benzazepin-1-yl]ethanoic acid amide

Participants

Role	Name	HCID	Charge
Reactant	3-bromo-5-phenyl-8-ethyl-2,3,4,5-tetrahydro-1H-(1)benzazepin-2-one	HCID 19961838	—
Reactant	N-(1-methylcyclohexyl)-iodoacetamide	HCID 19961840	—
Product	N-(1-Methylcyclohexyl)2-[3-bromo-2-oxo-5-phenyl-8-ethyl-2,3,4,5,-tetrahydro-1H-(1)benzazepin-1-yl]ethanoic acid amide	HCID 53849488	80%

Reaction Steps

Prepared as in Example 20I from 3-bromo-5-phenyl-8-ethyl-2,3,4,5-tetrahydro-1H-(1)benzazepin-2-one using N-(1-methylcyclohexyl)-iodoacetamide, M.P. 156°-158° C., 80% yield for the trans isomer.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05618811
Source dataset	uspto-grants-1997_04
ORD ID	ord-9bacc7daeed84a69b6f7d53067cc0bde
Source note	uspto-grants-1997_04