HCID 19037698, compound → HCID 53946091, compound

HRID 53141Notes

Reaction equation

HRID 53141 reaction equation
[Br:1][CH:2]1[CH2:8][CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]2[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:5]=2[NH:4][C:3]1=[O:20].[CH3:21][C:22]1([NH:28][C:29](=[O:32])[CH2:30]I)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH3:21][C:22]1([NH:28][C:29](=[O:32])[CH2:30][N:4]2[C:5]3[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:6]=3[CH:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH2:8][CH:2]([Br:1])[C:3]2=[O:20])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 19037698HCID 19037698, compoundHCID 19961840N-(1-methylcyclohexyl)-iodoacetamide

Product 1

HCID 53946091HCID 53946091, compound

Procedure

Prepared as in Example 20I from 3-bromo-5-phenyl-8-methyl-2,3,4,5-tetrahydro-1H-(1)benzazepin-2-one using N-(1-methylcyclohexyl)-iodoacetamide, M.P. x° C., x% yield for the trans isomer.

Workup

  1. custom, x% yield for the trans isomer

Sources & evidence

ORD record
ord-02e9a61fcfc8439181feb3cccbed9a68
Source dataset
uspto-grants-1997_04
Patent number
US05618811

Reaction notes

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