Tetrahydrofuran → HCID 90302550, compound

Participants

Reaction Steps

Hexyl 4-(phenylcarbamoyl)thiophene-3-carboxylate (4) (0.2949 g, 0.000890 mol), hexyl 2,5-dibromo-4-(phenylcarbamoyl)thiophene-3-carboxylate (7) (0.2952 g, 0.000890 mol), palladium catalyst (4% mol), ligand (8% mol) and Cs2CO3 (162.9 mg; 0.50 mmol) were put in a microwave vial with a magnetic stirring bar. Tetrahydrofuran (1 mL) was added and sealed. 5 cycles of freeze pump thaw was done and the reaction was kept at 120 degree Celsius for 48 hours. The whole mixture was cooled to room temperature and poured in 500 mL of cold methanol. The precipitate was filtered and dissolved in THF and precipitated again. This procedure was repeated 3 times to remove small molecules.

Provenance & Evidence