HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Iodosuccinimide → N-(3-(3-iodo-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | N-(3-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methanesulfonamide | HCID 58087575 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-(3-(3-iodo-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methanesulfonamide | HCID 90031153 | 50% |
Reaction Steps
Using similar reaction conditions as described in step i of intermediate 1, N-(3-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)methanesulfonamide (800 mg, 3 mmol) was iodinated with N-iodo succinimide (764 mg, 3 mmol) in acetone (5 ml) to afford 600 mg (50% yield) of the pure product. LCMS: m/z=413.4 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-ed80769ce66b491fada4a6f01f5bd4db |
| Source note | uspto-grants-2016_05 |