Sodium Carbonate → HCID 118524120, compound

Participants

Reaction Steps

Using the same reaction conditions as described in step-i of example 1,5-bromo-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine (Intermediate 1) (100 mg, 0.209 mmol) was coupled with (1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)boronic acid (103 mg, 0.524 mmol) using sodium carbonate (66 mg, 0.627 mmol) and Pd(PPh3)2Cl2 (7 mg, 0.0104 mmol) in DME/water (3/0.7 ml) to afford 60 mg (crude) product. MS: m/z=501.1 (M+1).

Provenance & Evidence