Hydrochloric Acid → HCID 90023150, compound

Participants

Reaction Steps

Using similar reaction conditions as described in (step i of Intermediate-2), tert-butyl piperazine-1-carboxylate (1.5 g, 6.81 mmol) was reacted with 4-bromo-1-fluoro-2-nitrobenzene (1.28 g, 6.81 mmol) in DMF (25 ml) and potassium carbonate (2.35 g, 17.02 mmol) to afford crude product. Using similar reaction conditions as described in Step-ii of example-7, above crude was deprotected in HCl in ether/methanol (10/10 ml). This afforded 2.0 g (99% yield).

Provenance & Evidence