HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 57960682, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | HCID 57960253 | HCID 57960253 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 57960682 | HCID 57960682 | 93.2% |
Reaction Steps
Using similar reaction conditions as described in step ii of Intermediate-27, 2-(4-(4-bromo-2-nitrophenyl)piperazin-1-yl)acetamide (600 mg, 1.74 mmol) was reduced using zinc dust (568 mg, 8.74 mmol) and ammonium chloride (461 mg, 8.74 mmol) in THF/water 10/10 ml to afford 508 mg (93% yield) of the titled product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-955cd13756e64d20ae5816d2a0ca9af4 |
| Source note | uspto-grants-2016_05 |