Lithium Hydroxide → N-(5-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methoxyphenyl)methanesulfonamide

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Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, N-(5-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methoxy phenyl)methanesulfonamide was hydrolyzed with lithium hydroxide (65 mg, 1.56 mmol) in THF/Methanol/water (10/3/2 mL). This yielded 22 mg (8.4% yield) of pure compound after purification by flash chromatography. 1H NMR (DMSO-d6, 300 MHz): δ 11.9 (s, 1H), 9.07 (s, 1H), 8.519-8.515 (d, 2H), 7.827-8.23 (d, 2H), 7.56-7.43 (m, 3H), 7.21-7.04 (m, 4H), 5.36 (s, 2H), 3.90 (s, 3H), 3.03 (s, 3H), 2.21-2.17 (d, 6H). MS: m/z=520.1 (M+1), HPLC: 95.74% (Method-B).

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