Toluene trifluoroacetic acid → N-(5-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(3-hydroxyprop oxy)phenyl)methanesulfonamide

Participants

Reaction Steps

A stirred solution of N-(5-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-(3-((4-methoxybenzyl)oxy)prop oxy)phenyl)methanesulfonamide (120 mg, 0.1 mmol), TFA/toluene (169 mg/3 mL) was heated to 80° C. for overnight. TLC showed reaction completion. Reaction mass was cooled to RT and solvents evaporated under reduced pressure. This afforded 60 mg of the crude titled compound. MS: m/z=718.2 (M+1).

Provenance & Evidence