HCID 118524084, compound → HCID 72943387, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 6-cyclopropyl-3-(1-(3,5-difluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-5-(4-methoxy-3-(methylsulfonamido)phenyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (70 mg, 0.103 mmol) was deprotected in HCl in 1,4-dioxane (2 ml). This afforded 5 mg (9.1% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.24 (s, 1H), 7.66 (s, 1H), 7.59-7.58 (m, 1H), 7.38-7.34 (dd, 1H), 7.22-7.19 (m, 1H), 6.93-6.90 (m, 1H), 6.82-6.76 (m, 1H), 5.45-5.39 (t, 2H), 3.96 (s, 3H), 2.94 (s, 3H), 2.5-2.4 (m, 1H), 2.25 (s, 3H), 1.4-1.0 (m, 4H). MS: m/z=538.1 (M+1), HPLC: 81% method B.

Provenance & Evidence