Lithium Hydroxide → HCID 90030668, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, 3-(4-(3-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl) propanenitrile (86 mg, 0.13 mmol) was hydrolyzed by lithium hydroxide (27 mg, 6.525 mmol), THF/Methanol/water (15/4/4 ml) to yield 5 mg (5.6% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.481 (s, 1H), 8.407-8.402 (d, 1H), 8.198 (s, 1H), 7.955 (s, 1H), 7.674 (s, 1H), 7.48-7.292 (m, 4H), 7.123-6.98 (m, 4H), 5.439 (s, 2H), 3.8-3.4 (m, 4H), 3.2-3.0 (t, 2H). MS: m/z=506.4 (M+1); HPLC: 98.91% in method A.

Provenance & Evidence