Formaldehyde → HCID 118524066, compound

Participants

Reaction Steps

A mixture of 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(3-(piperazin-1-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (step-i of example-35) (87 mg, 0.143 mmol), HCHO (13 mg, 0.43 mmol), 1,2-dichloroethane (2 ml) was stirred at RT under nitrogen for 30 minutes. Sodium triacetoxy borohydride (91 mg, 0.43 mmol) was then added and stirred at the same temperature for overnight. Reaction mass quenched water, basified by saturated sodium bicarbonate and extracted into ethyl acetate. Organic layer dried over sodium sulfate and concentrated to give 74 mg (84% yield) of the titled compound. MS: m/z=621.0 (M+1).

Provenance & Evidence