Hydrochloric Acid → HCID 72943514, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(3-(3-(1-(3-fluorobenzyl)-3-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (83 mg, 0.146 mmol) was deprotected in methanol (5 ml), HCl in dioaxane (5 ml). This afforded 20 mg (27.1% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.852-8.818 (m, 1H), 8.726-8.723 (d, 1H), 8.272 (s, 1H), 7.951 (s, 1H), 7.832-7.798 (d, 1H), 7.499-7.459 (t, 1H), 7.407-7.317 (m, 3H), 7.160-7.129 (m, 2H), 7.070-7.048 (m, 2H), 5.404 (s, 2H), 3.549-3.523 (m, 4H), 3.418-3.393 (m, 4H), 2.392 (s, 3H). MS: m/z=467.2 (M+1); HPLC: 94.845% in method A.

Provenance & Evidence