Hydrochloric Acid → HCID 90064824, compound

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Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(3-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (96 mg, 0.165 mmol) was deprotected in methanol (5 ml), HCl in dioaxane (5 ml). This afforded 20 mg (23.5% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.759-8.755 (d, 1H), 8.639-8.635 (d, 1H), 7.818 (s, 1H), 7.482-7.370 (m, 3H), 7.284-7.265 (d, 1H), 7.154-7.087 (m, 3H), 6.995-6.971 (m, 1H), 5.489 (s, 2H), 3.530-3.516 (m, 4H), 3.413-3.387 (m, 4H), 2.288 (s, 6H). MS: m/z=481.1 (M+1); HPLC: 85.59% in method A.

Provenance & Evidence