反应详情

Using similar reaction conditions as described in step-ii of example-1, tert-butyl 4-(4-(3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (intermediate 41) (130 mg, 0.19 mmol) was coupled with 1-(3-fluorobenzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate 16) (71 mg, 0.21 mmol) in sodium carbonate (40 mg, 0.38 mmol), PdCl2(dppf) (6.94 mg, 0.0095 mmol), 1,2-Dimethoxyethane/water (15/1.5 ml) to give titled compound quantity and yield as off white solid. MS: m/z=735.2 (M+1).

1. customreaction conditions