Hydrochloric Acid → HCID 118524079, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (80 mg, 0.137 mmol) was deprotected in dioxane (1 ml), HCl in dioxane (3 ml). This afforded 5 mg (23.5% yield) of the titled compound. 1H NMR (DMSO-d6, 300 MHz): δ 9.14-9.0 (b, 1H), 8.54 (d, 1H), 7.92 (s, 1H), 7.63-7.60 (s 2H), 7.54-7.53 (s, 1H), 7.5 (m, 1H), 7.10-7.04 (m, 5H), 5.34 (s, 2H), 3.41 (m, 4H), 3.25 (m, 4H), 2.17-2.14 (d, 4H). MS: m/z=481.2 (M+1), HPLC: 90.3% in Method B.

Provenance & Evidence