Hydrochloric Acid → HCID 118523972, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3,5-difluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (100 mg, 0.167 mmol) was deprotected in methanol (5 ml), HCl in 1,4-dioaxane (5 ml). This afforded 100 mg (63.3% yield) of the titled compound. 1H NMR (CDCl3, 300 MHz): δ 8.56 (s, 1H), 7.858-7.853 (d, 1H), 7.54-7.51 (d, 2H), 7.03-7.01 (d, 2H), 6.69-6.67 (m, 2H), 5.29 (s, 2H), 3.65-3.59 (t, 4H), 3.21-3.19 (t, 4H), 2.26 (s, 3H), 2.15 (s, 3H), 1.49 (s, 9H). MS: m/z=599.2 (M+1).

Provenance & Evidence