反应详情

Using similar reaction conditions as described in step-ii of example-1, 4-(4-(3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)morpholine (intermediate 43) (150 mg, 0.268 mmol) was coupled with 1-(3-fluorobenzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate 16) (133 mg, 0.402 mmol) in sodium carbonate (86 mg, 0.805 mmol), Pd(PPh3)2Cl2 (10 mg, 0.0134 mmol), Toluene/ethanol/water (5/5/5 ml) to afford 100 mg (58.82% yield) of titled compound. MS: m/z=636.1 (M+1).

1. customreaction conditions