2,8-Dichloro-4-piperidino-pyrimido [5,4-d]-pyrimidine → 2,8-Dichloro-4-(1,2,3,4-tetrahydro-isoquinolin-2-yl)-pyrimido [5,4-d]pyrimidine

HRID 53155Notes

Reaction equation

HRID 53155 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([Cl:12])[C:6]=2[N:7]=1>C1CCCCC1.C(OCC)(=O)C>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][C:16]3[C:15](=[CH:4][CH:5]=[CH:6][CH:8]=3)[CH2:14]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([Cl:12])[C:6]=2[N:7]=1

Participants

3

Reactant 1

HCID 135926182,8-Dichloro-4-piperidino-pyrimido [5,4-d]-pyrimidine

Product 1

HCID 537429562,8-Dichloro-4-(1,2,3,4-tetrahydro-isoquinolin-2-yl)-pyrimido [5,4-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 21867204Cyclohexane ethylacetateSolvent

Procedure

2,8-dichloro-4-piperidino-pyrimido [5,4-d]-pyrimidine Rf value: 0.66 (silica gel; cyclohexane/ethyl acetate=2:1)

Sources & evidence

ORD record
ord-8c988c9f3d6d410fb49f2fb51015be55
Source dataset
uspto-grants-1997_04
Patent number
US05618814

Reaction notes

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