HCID 90031554, compound → HCID 90030544, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (12 mg, 0.02 mmol) was deprotected in methanol/1,4-dioxane in (0.3/2 ml). This afforded 5 mg (55% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.72 (s, 1H), 8.669 (s, 1H), 7.85 (s, 1H), 7.71-7.69 (d, 2H), 7.42-7.39 (m, 2H), 7.32 (s, 1H), 7.24-7.18 (m, 3H), 5.52 (s, 2H), 3.53-3.50 (m, 4H), 3.41-3.38 (m, 4H), 2.33-2.32 (d, 6H). MS: m/z=497.2 (M+1), HPLC—95.77% (method-B).

Provenance & Evidence