tert-butyl 4-(4-(3-(3,5-dimethyl-1-(3-nitrobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate → tert-butyl 4-(4-(3-(1-(3-aminobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate

Participants

Reaction Steps

Using similar reaction conditions as described in example-8, tert-butyl 4-(4-(3-(3,5-dimethyl-1-(3-nitrobenzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (200 mg, 0.262 mmol) was reduced by 10% palladium on carbon (20 mg, 10% W/W), ethanol (3 mL) to yield 150 mg (yield 78.08%) of the titled compound. MS: m/z=7 32.3 (M+1).

Provenance & Evidence