HCID 86600365, compound → HCID 90031477, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(3,5-dimethyl-1-(3-methylbenzyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (20 mg, 0.034 mmol) was deprotected in methanol/1,4-dioxane HCl in (0.3/1 ml). This afforded 10 mg (63% yield) of the titled compound. 1H NMR (CD3OD, 400 MHz): δ 8.74 (s, 1H), 8.65 (s, 1H), 7.86 (s, 1H), 7.71-7.69 (d, 2H), 7.32-7.29 (t, 1H), 7.20-7.15 (m, 4H), 7.09-7.07 (d, 1H), 5.51 (s, 2H), 3.53-3.50 (m, 4H), 3.41-3.38 (m, 4H), 2.36-2.34 (m, 9H). MS: m/z=477.2 (M+1) HPLC 98.14% (method B).

Provenance & Evidence