Dichloromethane methanol → HCID 19962028, compound

HRID 53156Notes

Reaction equation

[Cl:1][C:2]1[N:3]=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([N:12]3CC[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][C:18]=4NC(=O)C)[CH2:13]3)[C:6]=2[N:7]=1.C(Cl)Cl.[CH3:35][OH:36]>>[Cl:1][C:2]1[N:3]=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([NH:12][CH2:13][C:14]3[CH:19]=[CH:18][C:17]([O:36][CH3:35])=[CH:16][CH:15]=3)[C:6]=2[N:7]=1

Participants

Reactant 2

HCID 21226129Dichloromethane methanol

HCID 544263962-Chloro-8-(5-acetylamino-1,2,3,4-tetrahydroisoquinolin-2-yl)-4-morpholino-pyrimido [5,4-d]pyrimidine

Product 1

HCID 19962028HCID 19962028, compound

Procedure

2-chloro-8-(5-acetylamino-1,2,3,4 -tetrahydroisoquinolin-2-yl)-4-morpholino-pyrimido [5,4-d]pyrimidine Rf value: 0.55 (silica gel; methylene chloride/methanol=9:1)

Sources & evidence

ORD record: ord-1037407dc81c4dafbb2c843023901722
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05618814

Reaction notes

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