Lithium Hydroxide → HCID 118523978, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(3,5-dimethyl-1-(3-(trifluoromethoxy)benzyl)-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (140 mg, 0.174 mmol) was hydrolyzed by lithium hydroxide (36.7 mg, 0.27 mmol), THF/Methanol/water (2/3/1 ml) to afford 90 mg (80.3% yield) of the titled compound. LCMS: m/z=647.2 (M+1).

Provenance & Evidence