Hydrochloric Acid → HCID 118524046, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-ethoxybenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazine-1-carboxylate (100 mg, 0.139 mmol) was deprotected with HCl in methanol (5 ml) to afford 4 mg (4.8% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.39-8.38 (d, 1H), 7.79-7.78 (d, 1H), 7.48-7.45 (m, 2H), 7.32 (s, 1H), 7.22-7.17 (t, 1H), 7.05-7.02 (d, 2H), 6.78-6.76 (dd, 1H), 6.69-6.67 (d, 1H), 6.59 (s, 1H), 5.27 (s, 2H), 3.95-3.93 (q, 2H), 3.95-3.57 (d, 2H), 3.26-3.19 (m, 4H), 3.05-3.02 (m, 2H), 2.16 (s, 3H), 2.12 (s, 3H), 1.30-1.26 (t, 3H). MS: m/z=507.3 (M+1), HPLC Purity: 92.87% Method: B.

Provenance & Evidence