HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 90031368, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(3-Fluoro-benzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole | HCID 90030671 | — |
| Reactant | HCID 90064815 | HCID 90064815 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethanol toluene water | HCID 86587398 | — |
| Product | HCID 90031368 | HCID 90031368 | — |
Reaction Steps
Using similar reaction conditions as described in step-ii of intermediate 1, 2-(4-(4-(3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)-N,N-dimethylethanamine (intermediate 49) (150 mg, 0.485 mmol) was coupled with 1-(3-fluorobenzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate 16) (157 mg, 0.477 mmol) in sodium carbonate (76 mg, 0.716 mmol), PdCl2(dppf) (8.7 mg, 0.011 mmol), Toluene/ethanol/water (15/7.5/1.5 ml) to afford 192 mg yield % of the crude titled compound. MS: m/z=706.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353107B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-2a69cff4873e4e359a32873062aeace8 |
| Source note | uspto-grants-2016_05 |