Sodium Carbonate → HCID 90031054, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-1, tert-butyl 4-(4-(3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-methoxyphenyl)piperazine-1-carboxylate (intermediate 52) (30 mg, 0.043 mmol) was coupled with 1-(3-fluorobenzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate 16) (17 mg, 0.052 mmol) in sodium carbonate (14 mg, 0.13 mmol), Pd(PPh3)2Cl2 (1.5 mg, 0.00218 mmol), Toluene/ethanol/water (2/1/0.5 ml) to afford 156.0 mg (crude) of titled compound. MS: m/z=766.3 (M+1).

Provenance & Evidence