Sodium Carbonate → HCID 90030785, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-1, tert-butyl 4-(4-(3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methoxyphenyl)piperazine-1-carboxylate (intermediate 58) (200 mg, 0.3 mmol) was coupled with 1-(3-fluorobenzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate 16) (130 mg, 0.13 mmol) in sodium carbonate (95 mg, 0.9 mmol), Pd(PPh3)2Cl2 (15 mg, 0.015 mmol), Toluene/ethanol/water (10/2/2.5 ml) to give 150 mg (64.65% yield) of titled compound. MS: m/z=765.3 (M+1).

Provenance & Evidence