Lithium Hydroxide → HCID 90030488, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-iii of example-1, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2-methoxy phenyl)piperazine-1-carboxylate (140 mg, 0.18 mmol) was hydrolyzed by lithium hydroxide (23 mg, 0.554 mmol), THF/Methanol/water (5/5/2 ml) to afford 70 mg of the titled compound. MS: m/z=610.9 (M+1).

Provenance & Evidence