Sodium Carbonate → HCID 90031536, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-1, tert-butyl 5-(4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)-2-cyclopropyl-3-iodo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (Intermediate 35) (50 mg, 0.07763 mmol) was coupled with 1-(3-fluorobenzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate 16) (30 mg, 0.08540 mmol) in sodium carbonate (25 mg, 0.2329 mmol), Pd(PPh3)4 (5 mg, 0.00388 mmol) and DME/water (5/1 ml) to afford 100 mg of the crude product which was taken as such for next reaction. MS: m/z=721.0 (M+1).

Provenance & Evidence