2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine → 4-(Dimethylaminomethyl)piperidine

HRID 53158Notes

Reaction equation

C(N(C1C2N=C([N:26]3[CH2:31][CH2:30][CH:29]([CH2:32][N:33]([CH3:35])[CH3:34])[CH2:28][CH2:27]3)N=C(N3CCOCC3)C=2N=CN=1)C)C1C=CC=CC=1.ClC1N=C(N2CCOCC2)C2N=CN=C(N(CC3C=CC=CC=3)C)C=2N=1>>[CH3:34][N:33]([CH2:32][CH:29]1[CH2:30][CH2:31][NH:26][CH2:27][CH2:28]1)[CH3:35]

Participants

Reactant 2

HCID 128170202-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine

HCID 541534238-(N-benzyl-N-methyl-amino)-2-[4-(N,N-dimethylaminomethyl)-piperidino]-4-morpholino-pyrimido [5,4-d]pyrimidine

Product 1

HCID 111372684-(Dimethylaminomethyl)piperidineYield 30.6%

Procedure

8-(N-benzyl-N-methyl-amino)-2-[4-(N,N-dimethylaminomethyl)-piperidino]-4-morpholino-pyrimido [5,4-d]pyrimidine From 2-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine and 4-(N,N-dimethylaminomethyl)-piperidine Yield: 30.6% of theory, Melting point: 145°-147° C. C26H36N8O (476.63)

Sources & evidence

ORD record: ord-816049a7da6b447d82ec4197253580b9
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05618814

Reaction notes

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