HCID 131735672, compound → HCID 90031226, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl (5-(3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-methoxypyridin-2-yl)carbamate (120 mg, 0.233 mmol) was deprotected in TFA/DCM (1/5 ml). This afforded 27 mg (21.9% yield) of the titled compound. 1H NMR (DMSO-d6, 400 MHz): δ 8.577-8.572 (d, 1H), 8.417-8.413 (d, 1H), 8.37 (s, 1H), 8.03 (s, 2H), 7.956-7.953 (d, 1H), 7.86-7.79 (s, 1H), 7.799-7.793 (d, 1H), 7.40-7.39 (q, 1H), 7.12-7.07 (m, 3H), 5.40 (s, 2H), 4.06 (s, 3H). MS: m/z=415.6 (M+1), HPLC: 93.86% in method A.

Provenance & Evidence