HCID 90031422, compound → HCID 90031051, compound

Participants

Reaction Steps

Using similar reaction conditions as described in step-ii of example-7, tert-butyl 4-(4-(3-(1-(3-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperidine-1-carboxylate (113 mg, 0.194 mmol) was deprotected in TFA/DCM (5/5 ml). This afforded 12 mg (12.9% yield) of the titled compound. 1H NMR (CD3OD, 300 MHz): δ 8.55 (s, 1H), 8.09-8.08 (d, 1H), 7.65-7.62 (m, 2H), 7.51 (s, 1H), 7.41-7.34 (m, 3H), 7.06-7.00 (m, 2H), 6.90-6.87 (s, 1H), 5.38 (s, 2H), 3.54-3.47 (m, 2H), 3.20-3.13 (m, 2H), 3.01-2.93 (m, 1H), 2.22 (s, 3H), 2.20 (s, 3H), 2.14-1.88 (m, 4H). MS: m/z=480.2 (M+1), HPLC: 98.73% in method B.

Provenance & Evidence